Each daughter cell must receive an exact copy of each and every chromosome. 每个子细胞必须获得每个染色体的精确复本。
Chromosome deletion was triggered by Cre/ loxP-mediated inverse sister chromatid recombination in the G2/ M phase of the cell cycle, leading to the generation of daughter cells missing part of or the entire recombinant chromosome. 在细胞有丝分裂的G2/M期,Cre/loxP介导的反向染色单体重组可以导致染色体删除,分裂后产生的子细胞将丢失全部或者部分的重组染色体。